Protocol of the Long-COVID Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients with Dysautonomia: The LoCoDiRe-Dys Study

Dysautonomia in the post-COVID-19 condition appears to affect a significant number of patients, with reports raising incidence up 61%, having an overlap myalgic encephalomyelitis/chronic fatigue syndrome. Quality life and daily function are significantly impacted conservative management interventions, despite lack high-quality evidence date, needed ameliorate disability. A total 50 adults dysautonomia diagnosis based on Ewing battery NASA lean test will be enrolled randomized single blinded controlled trial crossover design. Feasibility definite primary outcomes, while secondary outcomes health-related, clinical cardiopulmonary exercise indicators. Safety acceptance also checked, primarily excluding participants post-exertional malaise. The Long-COVID patients Causal Diagnosis Rehabilitation study (LoCoDiRE-Dys) intervention consist educational module, breathing retraining individualized biweekly sessions for two months regular assessment both groups. LoCoDiRe-Dys aims first people offering multimodal management. need effectively supporting is eminent.